By strengthening technological innovation, basic research, applied research, and achievement transformation, improve the ability of independent innovation in the field of medical devices to meet the needs of people's health, develop the domestic leading rapid prototyping application of human prosthesis reengineering polymer materials, and ensure the forward-looking of high-end medical devices , our company's R&D team uses complex surface reconfigurable technology to develop high-end medical equipment for skull personalized custom polymer material thermoforming.

　　Using the latest medical scientific research results of domestic skull repair, using electron beam CT three-dimensional reconstruction technology, successfully implemented digital skull repair technology for patients.

This electron beam CT three-dimensional reconstruction technology can three-dimensionally, detailedly and accurately display the condition of the skull defect and the relationship between the defect and the surrounding anatomical structures. It enables doctors to accurately understand and grasp the patient's condition, and then formulate a personalized surgical treatment plan for the patient. At the same time, according to the condition of the patient's skull defect, doctors simulate the natural shape of the skull, through CT data processing, medical three-dimensional reconstruction, surface rendering of the natural curved surface of the skull, computer graphics and image-aided design, and digital manufacturing of polymer materials. This program uses the results of 3D CT examinations to precisely design and prefabricate a personalized defect-repairing polymer skull for the patient, which is successfully fixed on the patient's defected head during the operation.

This technology realizes the precise combination of the polymer material skull and the defect site, realizes effective mechanical protection of the brain tissue, greatly shortens the operation time, greatly reduces the treatment risk, and reduces the pain of the patient, achieving a good treatment effect. In addition, using this technology, the most suitable polymer material mesh plate for the defect area of the patient can be pre-selected and the use of titanium nails during the operation can be reduced.

　　Aiming at the problem that the current additive manufacturing of polyetheretherketone (PEEK) personalized skull implants is far inferior to the injection molding process in strength, a new method combining additive manufacturing and injection molding technology—multi-point flexible injection molding process was proposed. Firstly, the continuous plane is discretized, and a large number of movable square steel needles are used to complete the construction of the inner surface of the flexible mold cavity by means of additive manufacturing; secondly, the PEEK personalized skull implant is manufactured by injection molding; Finally, the step effect was removed by grinding and polishing, and a high-performance PEEK personalized skull repair implant was obtained. Research and evaluation through process analysis, precision analysis and in vitro cytotoxicity experiments show that the average deviation of the skull model samples produced by this method is 0.475~-0.409mm, and the strength of the produced tensile samples is 72.15~83.26mm. MPa, which can meet the precision and mechanical performance requirements of skull repair implants. In the in vitro cytotoxicity test, the survival rate of the cells cultured in the extraction solution of the injection molding raw material group and the trial sample group reached over 90%, which proves that the materials used in the multi-point flexible injection molding process are non-toxic, and no New toxic substances can meet the biocompatibility requirements of cranioplasty implants. Therefore, this method can produce low-cost, high-performance, and non-cytotoxic personalized skull repair implants, which has important application prospects in skull repair.